Surya prakash singh, mrinalini sharma and pradeep kumar gupta, cytotoxicity of curcumin silica nanoparticle complexes conjugated with hyaluronic acid on colon cancer cells, international journal of. In recent years, nanotechnology has been proven to offer promising biomedical applications for in vivo diagnostics and drug delivery, stressing the importance of thoroughly. Application of hyaluronic acid in tissue engineering. Development of multidrug resistance mdr is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic.
Pdf selfassembled hyaluronic acid nanoparticles for active tumor. Given its merits, such as its selective distribution at tumor sites and its controllable. Hyaluronic acidcoated bovine serum albumin nanoparticles loaded with brucine as selective nanovectors for intraarticular injection zhipeng chen, juan chen, li wu, weidong li, jun chen, haibo cheng. We created a polyethylenimine pei coated mesoporous silica nanoparticle msn conjugated with hyaluronic acid msnha. Pdf to develop a nanosized drug delivery system for cancer therapy, amphiphilic hyaluronic acid conjugates were synthesized by chemical conjugation. Hyaluronic acidcoated chitosan nanoparticles induce ros. Nanoparticle fabrication and the effect of process parameters on size and charge of. Instead of nonspecific polyethylene glycol peg conjugated interferon. Theranostic approach of hyaluronic acidbased nanoparticle. Kolar2 1faculty of medicine and dentistry, palacky university. Engineering of lipid prodrugbased, hyaluronic aciddecorated nanostructured lipid carriers platform for 5fluorouracil and cisplatin combination gastric cancer therapy chunying qu,1, min zhou,1, yingwei. Since aggressive cancer cells highly express the cd44 receptor compared to normal cells, hyaluronic acid ha can be used for cd44 targeting. The adsorption of gold seeds is successfully achieved through chelation.
Different molecular weights of hyaluronic acid play a role in formation of. Superparamagnetic iron oxide nanoparticles spions conjugated with hyaluronic acid ha functional groups have potential applications as cell targeting materials. Pdf hyaluronic acid nanoparticles hanps, which are formed by the selfassembly of hydrophobically modified ha derivatives, were. Pgma microspheres are synthesized by emulsifierfree emulsion polymerization followed by amination. We have previously shown effective delivery to tumor cells using a similar modality, both in vitro and in vivo of ovarian, melanoma, and breast cancer. Hyaluronic acidbased nanomaterials for cancer therapy mdpi.
Hyaluronic acidcoated nanoparticles as biofunctional. Gold nanoparticlebased rapid detection and isolation of. Lijia jing 1, shangmin shao 3, yang wang 3, yongbo yang. Exploring the relationship of hyaluronic acid molecular weight and. For these systems, unequivocal links have not been. Hyaluronicacid based nanocarriers for rnai therapy of. Blank nanoparticles np made of ha and paoh were obtained using the ionic gelation technique. Pdf effects of organic solvents on hyaluronic acid.
Pdf selfassembled hyaluronic acid nanoparticles as a potential. Complexes of silveri ions and silver phosphate nanoparticles with hyaluronic acid andor chitosan as promising antimicrobial agents for vascular grafts by dagmar chudobova 1, lukas nejdl 1, jaromir. Chitosanhyaluronic acid ha nanoparticles can be used to deliver an rnadna cargo to cells overexpressing ha receptors such as cd44. Gold nanoparticles aunps have been extensively investigated as an emerging delivery carrier of various biopharmaceuticals. Design and development of blank, fluorescent and dachptloaded hyaluronic acid polyarginine nanoparticles. Application of hyaluronic acid in tissue engineering 1. Turnover and possible pathways for elimination of hyaluronic acid 1. Hyaluronic acid is one of the major elements in the extracellular matrix ecm of vertebrate. Orally targeted delivery of tripeptide kpv via hyaluronic. After acid etching, pvp coated hollow pb nanoparticles were obtained by centrifugation and washed with di water and ethanol three times. This study aimed to evaluate the passive delivery into skin of ha nanoparticles formed by. Cd44 receptor and mitochondria targeting hyaluronic acid d.
While lpt is one of the dual tyrosine kinase inhibitors for epidermal growth factor receptor egfr and human egfr2 her2, tnbc cells. Request pdf hyaluronic acid bound letrozole nanoparticles restore sensitivity to letrozoleresistant xenograft tumors in mice letrozole is a potent aromatase inhibitor and superior to other. In this study, we developed curcuminencapsulated hyaluronic acidpolylactide nanoparticles cehpnps to be used for liver. A targeted drug nanoparticle np delivery system has shown potential as a possible cancer treatment. Structural characterisation of hyaluronic acidcoated chitosan nanoparticles. Among these, hyal1 and hyal2 have been studied the most. Marija milovanovic, aleksandar arsenijevic, jelena. Ovarian cancer targeted hyaluronic acidbased nanoparticle. A composite of hyaluronic acidmodified graphene oxide and iron oxide. This study aimed to evaluate the passive delivery into skin of ha nanoparticles formed by the.
Smart nanoparticles based on hyaluronic acid for redox. Additional ionic crosslinking using various cations is introduced after an in situ precipitation process for hydroxyapatite immobilization in hyaluronic acid hydrogels haccap. Preparation and photothermal therapy of hyaluronic acid. We prepared pphenylenediamine pdaincorporated nanoparticles using hyaluronic acid ha. Hyaluronic acid modified hollow prussian blue nanoparticles loading 10hydroxycamptothecin for targeting thermochemotherapy of cancer. Hyaluronicacid based nanocarriers for rnai therapy of advanced sepsis author. Preparation and investigation of crosslinked hyaluronic. Pdf hyaluronic acid nanoparticles hanps, which are formed by the self assembly of hydrophobically modified ha derivatives, were. Hyaluronic acidcoated nanoparticles as biofunctional pharmaceutical carriers a thesis submitted to the university of manchester for the degree of doctor of philosophy in the faculty of medical and human. Bioinspired hyaluronic acid and polyarginine nanoparticles. Hyaluronic acid ha is a natural mucopolysaccharide that consists of alternating residues dglucuronic acid and nacetyldglucosamine. Hyaluronic acid conjugated nanoparticle delivery of sirna. Degraded hyaluronic acidmodified magnetic nanoparticles.
Although it is reported that the targeting ability of hyaluronic acid habased nanoparticles nps is molecular weight mw dependent, the influence of ha mw. Targeting mapkpi3k signaling hub in colon cancer cells sandeep palvai, meenu mahesh kuman, poulomi sengupta, and sudipta basu. The nanoparticles are composed of hyaluronic acid ha and chitosan. Restoring hyaluronic acid ha content is important for maintaining the function of photoaged skin. Cellular responses of hyaluronic acidcoated chitosan. A method for synthesizing uniformly sized hyaluronic acid ha particles that are substantially free from oil and surfactant contaminants. In this study, nanoparticles were prepared via complexation with triphosphate tpp anions and. Photocrosslinked hyaluronic acid coated upconverting nanoparticles. A hydrodynamic flow focusing hff approach is proposed to produce through a onestep process multimodal pegylated crosslinked hyaluronic acid nanoparticles pegchanps. Hyaluronic acidbound letrozole nanoparticles restore. Effects of organic solvents on hyaluronic acid nanoparticles obtained by precipitation and chemical crosslinking article pdf available in journal of nanoscience and nanotechnology 123. Hyaluronic acid layerbylayer lbl nanoparticles for. Full text engineering of lipid prodrugbased, hyaluronic.
Since the representative hallmark of atherosclerosis in its pathogenic process is the overexpression of the receptors for hyaluronic acid ha such as stabilin2 and cd44, we herein investigated the potential. Enhancing chemoradiation of colorectal cancer through. Mdr1 sirna loaded hyaluronic acid based cd44 targeted. Hyaluronic aciddecorated chitosan nanoparticles for cd44targeted delivery of everolimus. A hyaluronic acid functionalized chimeric viralnonviral nanoparticle comprising. Nano hyaluronic stem cell serum platinum skin care. Nanocomposites are fabricated with poly glycidyl methacrylate pgma microspheres, au nanoparticles and hyaluronic acid ha for accurate photothermal therapy. Identification and isolation of lowfrequency cells of interest from a heterogeneous cell mixture is an important aspect of many diagnostic applications including enumeration of circulating. The aim of this study was to design hyaluronic acid ha layerbylayer lbl nanoparticles, which carried paclitaxel ptx and indocyanine green icg to both tumor cells and. Application of hyaluronic acid in osteoarthritis treatment 1. Synthesis of hyaluronic acid grafting polyethylene glycol hagpeg. Ameliorative effect of curcuminencapsulated hyaluronic. Ha plays a key role in the structure and organization of the. The hyaluronic acidupconversion nanoparticle conjugate of claim 5, wherein a weight ratio of the upconversion nanoparticle to the hyaluronic acid or the derivative of hyaluronic acid is 1.
Graphene oxide go nanoparticles have been developed for a variety of. Chitosan nanoparticles are popular carriers for the delivery of macromolecular payloads, e. Biomedical application of hyaluronic acid nanoparticles. Hyaluronic acid also known as a glycosaminoglycan is often touted for its ability to reverse or stop aging. Hyaluronic aciddecorated chitosan nanoparticles for cd44. A composite of hyaluronic acidmodified graphene oxide and iron. Pdaincorporated ha nanoparticles have spherical shapes and sizes were less than 300 nm. Mitochondria targeting and destabilizing hyaluronic acid. Hyaluronic acid nanoparticles for active targeting. We have previously shown effective delivery to tumor cells using a similar. Hyaluronic acidcoated bovine serum albumin nanoparticles. Combined modality therapy incorporating raltitrexed rtx, a thymidylate synthase inhibitor, and radiation can lead to improved outcome for rectal cancer patients. Mdr1 sirna loaded hyaluronic acidbased cd44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer the harvard community has made this article openly available. You may have heard of hyaluronic acid as the key to the fountain of youth.
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